No Priors: Artificial Intelligence | Technology | Startups
Biohub: The Future of Biology is Open-Source with Co-Founders Mark Zuckerberg, Priscilla Chan, and Head of Science Alex Rives
At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com.
Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners.
Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
Show Notes
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Biohub started with an ambitious goal of curing, preventing, and managing all disease by the end of the century. A decade later, thanks to the convergence of frontier AI and biological data, that goal may have been too conservative. In this episode, Elad Gil and Sarah Guo sit down with Biohub co-founders Mark Zuckerberg and Priscilla Chan, alongside Biohub Head of Science Alex Rives. Together, they discuss Biohub’s $500 million virtual biology initiative, which integrates frontier AI with wet-lab work to build predictive world models of cells, proteins, and systems. They also talk about their newly announced open-source engine for digital protein and antibody design, ESMFold2; why Biohub is a nonprofit rather than a venture-backed startup; and how hierarchical simulations will soon allow doctors to treat patients at an individual, mechanistic level.
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Chapters:
– Cold Open
Mark Zuckerberg, Priscilla Chan, and Alex Rives Introduction
– Why Biohub and Their Mission
– Integrating Frontier AI and Frontier Biology
– Micro to Macro Biological Modeling
– Mechanistic Interpretiability
– Why Biohub is a Non-Profit
– Understanding How Biology Works
– Timeline for Curing All Diseases
– Translating Research to Patient Impact
– Launch of ESMFold2
– Tackling Off-Target Effects and Edge Cases
– Putting the Tech in Individual Hands
– Talent at Biohub
– What’s Next After ESMFold2
– Connecting ESMFold2 to Agentic Systems
– The Virtual Cell
– Defining Success for Biohub
– Biohub Strategy Update
– Conclusion
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