Dwarkesh Podcast
Evolution designed us to die fast; we can change that — Jacob Kimmel
Deeply researched interviews <br/><br/><a href="https://www.dwarkesh.com?utm_medium=podcast">www.dwarkesh.com</a>
Show Notes
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Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene delivery and Jacob’s controversial takes on CAR-T cells. For full disclosure, I am an angel investor in NewLimit. This did not impact my decision to interview Jacob, nor the questions I asked him.
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TIMESTAMPS
() – Three reasons evolution didn’t optimize for longevity
() – Why didn't humans evolve their own antibiotics?
() – De-aging cells via epigenetic reprogramming
() – Viral vectors and other delivery mechanisms
() – Synthetic transcription factors
() – Can virtual cells break Eroom’s Law?
() – Economic models for pharma
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