Dwarkesh Podcast
Evolution designed us to die fast; we can change that — Jacob Kimmel
Deeply researched interviews <br/><br/><a href="https://www.dwarkesh.com?utm_medium=podcast">www.dwarkesh.com</a>
Show Notes
Tap timecodes to jump
Jacob Kimmel thinks he can find the transcription factors to reverse aging. We do a deep dive on why this might be plausible and why evolution hasn’t optimized for longevity. We also talk about why drug discovery has been getting exponentially harder, and what a new platform for biological understanding to speed up progress would look like. As a bonus, we get into the nitty gritty of gene delivery and Jacob’s controversial takes on CAR-T cells. For full disclosure, I am an angel investor in NewLimit. This did not impact my decision to interview Jacob, nor the questions I asked him.
Watch on YouTube; listen on Apple Podcasts or Spotify.
SPONSORS
* Hudson River Trading uses deep learning to tackle one of the world's most complex systems: global capital allocation. They have a massive in-house GPU cluster, and they’re constantly adding new racks of B200s to ensure their researchers are never constrained by compute. Explore opportunities at hudsonrivertrading.com/dwarkesh\
* Google’s Gemini CLI turns ideas into working applications FAST, no coding required. It built a complete podcast post-production tool in 10 minutes, including fully functional backend logic, and the entire build used less than 10% of Gemini’s session context. Check it out on Github now!
* To sponsor a future episode, visit dwarkesh.com/advertise.
TIMESTAMPS
() – Three reasons evolution didn’t optimize for longevity
() – Why didn't humans evolve their own antibiotics?
() – De-aging cells via epigenetic reprogramming
() – Viral vectors and other delivery mechanisms
() – Synthetic transcription factors
() – Can virtual cells break Eroom’s Law?
() – Economic models for pharma
Get full access to Dwarkesh Podcast at www.dwarkesh.com/subscribe
Transcript not yet processed.
Sign in to unlock (1 credit)
Free to start
Full transcripts, AI insights,
Full transcripts, AI insights,
episode chat — free.
Sign up with Google in one click. 10 unlock credits included. No card needed.
Google sign-in · No credit card · Cancel anytime